Frequently Asked Questions Are there any employment opportunities? Expand Regional Information Major Highways: Expand State Routes 5 and 6, routes through the City Near State Route 63 Near I-35 Distance From Major Airports: Expand KC International 128.20 miles 2 hrs. 23 minutes Lambert-St. Louis 236.88 miles 4 hrs. 58 minutes Smaller airport nearer Milan but with good and improving commercial service: Expand Kirksville Regional Airport, Kirksville, MO 41.5 miles Distance from Major Cities: Expand Kansas City, MO/KS 126 miles approx. 2 hrs. 30 minutes, SW St. Louis, MO 245 miles approx. 3 hrs., E Columbia, MO 125 miles approx. 2 hrs. 15 minutes, SE Des Moines 128 miles approx. 2 hrs. 45 minutes, N In addition, rail service is available 12.20 miles (16 minutes) away in Osgood, Missouri.